MelanoSITE™
Aurora Diagnostics, DermDX division is pleased to offer access to MelanoSITE™ one of the first commercially available FISH assays that will aid in the diagnosis of Melanoma.
Most melanomas can be distinguished from benign nevi histologically.
However, a considerable number of cases show conflicting
morphologic criteria. There are many types of melanocytic nevi that
resemble melanoma and variants of melanoma that resemble nevi leading to diagnostic ambiguity.
Diagnostic ambiguity has significant implications for patients.
• Unwanted Procedures
• Unnecessary Scars
• Emotional Strain
• Mortality
• Litigation
Having access to relevant, leading-edge technologies means that you and your patients benefit from the improved classification of melanocytic neoplasms with conflicting morphologic features, that your patient treatment options will be based on accurate diagnosis and that your practice will be recognized for ensuring access to the most relevant, innovative testing available.
FISH
Fluorescence in situ Hybridization (FISH) can help identify subtle structural rearrangement, variant chromosomes, and submicroscopic changes not readily discernable by classic cytogenetics. FISH relies on three technologies: cytogenetics, DNA hybridization and fluorescence microscopy to provide another level of laboratory testing. FISH utilizes DNA probes comprised of specific nucleic acid sequences tagged with a fluorescent marker.
MelanoSITE™ 4 Probe Assay
As a diagnostic aid to traditional histologic evaluation, this assay can have significant clinical impact and improve classification of melanocytic neoplasms with conflicting morphologic criteria.
Hear from the Expert
Dr. Pedram Gerami, M.D.
Northwestern University
Development and Application of a Targeted Fluorescence In Situ Hybridization Assay for Distinguishing Melanoma from Benign Nevi. Video
Reference
1. Gerami, P., Jewell, S., Morrison, L., Blondin, B., Schulz, J., Ruffalo, T., Matushek, P., Legator, M., Jacobson, K., Dalton, S., Charzan, S., Kolaitis, N., Guitart, J.,
Lertsbarapa, T., Boone, S., LeBoit, P., Bastian, B. Fluorescence In Situ Hybridization (FISH) as an Ancillary Diagnostic Tool in the Diagnosis of Melanoma, Am J Surg Pathol, Vol 2009 Aug;33(8):1146-56.
2. Validation of a Laboratory Developed Test (LDT). Data on file, NeoGenomics Laboratories, Inc. *Calculated PPV and NPV based upon performance characteristics applied to population statistics.